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Main information about Prednisone

Prednisone is a glucocorticoid hormone drug which has a strong anti-inflammatory and anti-allergic action. This is a medical analogue of the adrenocortical hormones which is for supplementing of this hormone deficit.

Prednisone plays a function of the adrenocortical hormones, and therefore it has a broad action. This drug is used in the treatment of many pathologies:

• Diseases of the skin
• Allergic diseases
• Connective tissue diseases
• Severe renal and adrenal diseases
• Inflammatory diseases of the joints, bones and ligaments
• Severe cardiovascular pathologies
• Serious disorders of the liver

Prednisone is able to restore a metabolism disorder and regulate a balance of water, salts and minerals in the body tissues. During the use of this drug, the level of glucose is increased in the blood, the fatty tissue is redistributed, protein degradation occurs in the muscle and bone tissues, water retain happens in the body, and the blood pressure is increased.

Using Prednisone blocks a production of the biological ingredients which take part in the formation of the inflammatory and allergic reactions. And if the common NSAID acts to certain receptors and enzymes for the local reduction of the inflammatory process, Prednisone acts in the entire body and activates all biologically active substances. The same happens during severe allergic reaction.

Use and dose of Prednisone

Prednisone is used under doctor’s control. The uncontrolled use of this drug may cause serious hormonal disorders which will cause complications and side effects. The tablets of Prednisone should be orally used with a glass of water. To achieve a therapeutic effect, patients are prescribed a high daily dose of Prednisone 20-30 mg.

To achieve a medical effect and reduce the disease symptoms, a dose is gradually lowered up to 5-10 mg per day. The optimal maintaining dose of Prednisone is 5-15 mg per day.

Children are prescribed Prednisone in the dose of 1-2 mg per 1 kg of the body weight. The daily dose is divided into 4-5 times in order to reduce a risk of the side effects.

A length of the use of Prednisone may vary – 1 month to several years. It all depends on the individual peculiarities and a therapy efficiency.

Recommendations for the use

• As Prednisone increases the blood pressure, patients with intense hypertension should not take it
• Prednisone reduces an efficiency of the hypoglycemic products, and therefore if you have pancreatic diabetes, consult a doctor before taking Prednisone
• Do not take Prednisone during tuberculosis, viral infections, kidney failure, and during pregnancy.
• The treatment is gradually stopped in order to prevent a withdrawal syndrome

Side effect

As other hormonal drugs, Prednisone may cause some side effects related to a change of the biochemical processes in the body.

An administration of Prednisone may be accompanied by the following symptoms: the development of edema, hyperglycemia, increased blood pressure, fatigue, general muscle weakness, nervous agitation, insomnia, psychosis, and convulsions.

To reduce the side effects, patients should reduce the daily dose and have a supportive care.